6PXU

Crystal structure of human GalNAc-T12 bound to a diglycosylated peptide, Mn2+, and UDP

Summary for 6PXU

Entry DOI	10.2210/pdb6pxu/pdb
Descriptor	Polypeptide N-acetylgalactosaminyltransferase 12, GAGATGAGAGYYITPRTGAGA, URIDINE-5'-DIPHOSPHATE, ... (8 entities in total)
Functional Keywords	galnac-t, mucin-type o-glycosylation, enzyme catalysis, substrate selectivity, colorectal cancer, crc, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	132554.37
Authors	Samara, N.L.,Fernandez, A.J. (deposition date: 2019-07-27, release date: 2019-09-25, Last modification date: 2023-10-11)
Primary citation	Fernandez, A.J.,Daniel, E.J.P.,Mahajan, S.P.,Gray, J.J.,Gerken, T.A.,Tabak, L.A.,Samara, N.L. The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function. Proc.Natl.Acad.Sci.USA, 116:20404-20410, 2019 Cited by PubMed: 31548401 DOI: 10.1073/pnas.1902211116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.007 Å)

Structure validation