6PXU

Crystal structure of human GalNAc-T12 bound to a diglycosylated peptide, Mn2+, and UDP

6PXU の概要

• エントリーDOI: 10.2210/pdb6pxu/pdb
• 分子名称: Polypeptide N-acetylgalactosaminyltransferase 12, GAGATGAGAGYYITPRTGAGA, URIDINE-5'-DIPHOSPHATE, ... (8 entities in total)
• 機能のキーワード: galnac-t, mucin-type o-glycosylation, enzyme catalysis, substrate selectivity, colorectal cancer, crc, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 132554.37

構造登録者

Samara, N.L.,Fernandez, A.J. (登録日: 2019-07-27, 公開日: 2019-09-25, 最終更新日: 2023-10-11)

• 主引用文献: Fernandez, A.J.,Daniel, E.J.P.,Mahajan, S.P.,Gray, J.J.,Gerken, T.A.,Tabak, L.A.,Samara, N.L.; The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function.; Proc.Natl.Acad.Sci.USA, 116:20404-20410, 2019; PubMed: 31548401; DOI: 10.1073/pnas.1902211116

実験手法

X-RAY DIFFRACTION (2.007 Å)