6PXA

The crystal structure of chloramphenicol acetyltransferase-like protein from Vibrio fischeri ES114 in complex with taurocholic acid

6PXA の概要

• エントリーDOI: 10.2210/pdb6pxa/pdb
• 関連するPDBエントリー: 5UX9
• 分子名称: Chloramphenicol acetyltransferase, TAUROCHOLIC ACID, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: structural genomics, center for structural genomics of infectious diseases, csgid, transferase
• 由来する生物種: Aliivibrio fischeri (strain ATCC 700601 / ES114)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 305234.92

構造登録者

Tan, K.,Maltseva, N.,Jedrzejczak, R.,Kuhn, M.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2019-07-25, 公開日: 2019-09-25, 最終更新日: 2025-06-18)

主引用文献

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, :e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

実験手法

X-RAY DIFFRACTION (1.82 Å)