6PVE

Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL319

6PVE の概要

• エントリーDOI: 10.2210/pdb6pve/pdb
• 分子名称: NNMT protein, 9-(5-{[(3S)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)propyl]amino}-5-deoxy-alpha-D-ribofuranosyl)-9H-purin-6-amine (3 entities in total)
• 機能のキーワード: methyltransferase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127978.38

構造登録者

Noinaj, N.,Huang, R.,Chen, D.,Yadav, R. (登録日: 2019-07-20, 公開日: 2019-11-27, 最終更新日: 2024-03-13)

• 主引用文献: Chen, D.,Li, L.,Diaz, K.,Iyamu, I.D.,Yadav, R.,Noinaj, N.,Huang, R.; Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase.; J.Med.Chem., 62:10783-10797, 2019; PubMed: 31724854; DOI: 10.1021/acs.jmedchem.9b01255

実験手法

X-RAY DIFFRACTION (2.3 Å)