6PVB
The structure of NTMT1 in complex with compound 6
Summary for 6PVB
Entry DOI | 10.2210/pdb6pvb/pdb |
Descriptor | N-terminal Xaa-Pro-Lys N-methyltransferase 1, AMINO GROUP-()-(2~{S})-2-azanylpropanal-()-ISOLEUCINE-()-ARGININE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
Functional Keywords | methyltransferase, enzyme, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28748.76 |
Authors | Noinaj, N.,Chen, D.,Huang, R. (deposition date: 2019-07-20, release date: 2020-08-19, Last modification date: 2023-11-15) |
Primary citation | Chen, D.,Dong, C.,Dong, G.,Srinivasan, K.,Min, J.,Noinaj, N.,Huang, R. Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues. J.Med.Chem., 63:8419-8431, 2020 Cited by PubMed: 32605369DOI: 10.1021/acs.jmedchem.0c00770 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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