6PVB

The structure of NTMT1 in complex with compound 6

6PVB の概要

• エントリーDOI: 10.2210/pdb6pvb/pdb
• 分子名称: N-terminal Xaa-Pro-Lys N-methyltransferase 1, AMINO GROUP-()-(2~{S})-2-azanylpropanal-()-ISOLEUCINE-()-ARGININE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• 機能のキーワード: methyltransferase, enzyme, inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28748.76

構造登録者

Noinaj, N.,Chen, D.,Huang, R. (登録日: 2019-07-20, 公開日: 2020-08-19, 最終更新日: 2023-11-15)

• 主引用文献: Chen, D.,Dong, C.,Dong, G.,Srinivasan, K.,Min, J.,Noinaj, N.,Huang, R.; Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.; J.Med.Chem., 63:8419-8431, 2020; PubMed: 32605369; DOI: 10.1021/acs.jmedchem.0c00770

実験手法

X-RAY DIFFRACTION (1.5 Å)