6PQO

Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010

6PQO の概要

• エントリーDOI: 10.2210/pdb6pqo/pdb
• EMDBエントリー: 20449 20450 20451
• 分子名称: Transient receptor potential cation channel subfamily A member 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ... (5 entities in total)
• 機能のキーワード: ion channel, trp channel, trpa channel, trpa1 channel, irritant sensing, jt010, membrane protein, transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 546667.74

構造登録者

Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.-R.,Lee, S.-Y. (登録日: 2019-07-09, 公開日: 2020-01-08, 最終更新日: 2020-07-29)

• 主引用文献: Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.R.,Lee, S.Y.; Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.; Neuron, 105:882-, 2020; PubMed: 31866091; DOI: 10.1016/j.neuron.2019.11.023

実験手法

ELECTRON MICROSCOPY (2.88 Å)