6PQB

Crystal structure of aminoglycoside-resistance methyltransferase RmtC bound to S-adenosylhomocysteine (SAH)

6PQB の概要

• エントリーDOI: 10.2210/pdb6pqb/pdb
• 関連するPDBエントリー: 3FRH 3FZG 3LCV 6CN0
• 分子名称: 16S rRNA (guanine(1405)-N(7))-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• 機能のキーワード: methyltransferase, ribosome, aminoglycoside resistance, s-adenosylhomocysteine, transferase
• 由来する生物種: Proteus mirabilis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130701.50

構造登録者

Nosrati, M.,Hoffer, E.D.,Conn, G.L. (登録日: 2019-07-08, 公開日: 2019-10-16, 最終更新日: 2023-10-11)

• 主引用文献: Nosrati, M.,Dey, D.,Mehrani, A.,Strassler, S.E.,Zelinskaya, N.,Hoffer, E.D.,Stagg, S.M.,Dunham, C.M.,Conn, G.L.; Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition.; J.Biol.Chem., 294:17642-17653, 2019; PubMed: 31594862; DOI: 10.1074/jbc.RA119.011181

実験手法

X-RAY DIFFRACTION (3.14 Å)