6PLG

Crystal structure of human PHGDH complexed with Compound 15

6PLG の概要

• エントリーDOI: 10.2210/pdb6plg/pdb
• 分子名称: D-3-phosphoglycerate dehydrogenase, (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid, D-MALATE (3 entities in total)
• 機能のキーワード: dehydrogenase, serine metabolism, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 273665.40

構造登録者

Olland, A.,Lakshminarasimhan, D.,White, A.,Suto, R.K. (登録日: 2019-06-30, 公開日: 2019-07-24, 最終更新日: 2019-09-04)

• 主引用文献: Mullarky, E.,Xu, J.,Robin, A.D.,Huggins, D.J.,Jennings, A.,Noguchi, N.,Olland, A.,Lakshminarasimhan, D.,Miller, M.,Tomita, D.,Michino, M.,Su, T.,Zhang, G.,Stamford, A.W.,Meinke, P.T.,Kargman, S.,Cantley, L.C.; Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.; Bioorg.Med.Chem.Lett., 29:2503-2510, 2019; PubMed: 31327531; DOI: 10.1016/j.bmcl.2019.07.011

実験手法

X-RAY DIFFRACTION (2.93 Å)