6PL4
TRK-A IN COMPLEX WITH LIGAND 1
Summary for 6PL4
Entry DOI | 10.2210/pdb6pl4/pdb |
Descriptor | High affinity nerve growth factor receptor, N-{[5-(methoxymethyl)-2-(trifluoromethoxy)phenyl]methyl}-N'-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)urea (3 entities in total) |
Functional Keywords | trk-a kinase domain, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35914.18 |
Authors | Subramanian, G.,Brown, D.G. (deposition date: 2019-06-30, release date: 2020-07-01, Last modification date: 2021-11-03) |
Primary citation | Subramanian, G.,Duclos, B.,Johnson, P.D.,Williams, T.,Ross, J.T.,Bowen, S.J.,Zhu, Y.,White, J.A.,Hedke, C.,Huczek, D.,Collard, W.,Javens, C.,Vairagoundar, R.,Respondek, T.,Zachary, T.,Maddux, T.,Cox, M.R.,Kamerling, S.,Gonzales, A.J. In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain Acs Med.Chem.Lett., 2021 Cited by DOI: 10.1021/acsmedchemlett.1c00483PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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