6PL4

TRK-A IN COMPLEX WITH LIGAND 1

6PL4 の概要

• エントリーDOI: 10.2210/pdb6pl4/pdb
• 分子名称: High affinity nerve growth factor receptor, N-{[5-(methoxymethyl)-2-(trifluoromethoxy)phenyl]methyl}-N'-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)urea (3 entities in total)
• 機能のキーワード: trk-a kinase domain, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35914.18

構造登録者

Subramanian, G.,Brown, D.G. (登録日: 2019-06-30, 公開日: 2020-07-01, 最終更新日: 2021-11-03)

• 主引用文献: Subramanian, G.,Duclos, B.,Johnson, P.D.,Williams, T.,Ross, J.T.,Bowen, S.J.,Zhu, Y.,White, J.A.,Hedke, C.,Huczek, D.,Collard, W.,Javens, C.,Vairagoundar, R.,Respondek, T.,Zachary, T.,Maddux, T.,Cox, M.R.,Kamerling, S.,Gonzales, A.J.; In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain; Acs Med.Chem.Lett., 2021; DOI: 10.1021/acsmedchemlett.1c00483

実験手法

X-RAY DIFFRACTION (2.06 Å)