6PL3

TRK-A IN COMPLEX WITH LIGAND 2a

Summary for 6PL3

Entry DOI	10.2210/pdb6pl3/pdb
Descriptor	High affinity nerve growth factor receptor, 2-[(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)amino]-2-oxoethyl 4-(1H-tetrazol-1-yl)benzoate (3 entities in total)
Functional Keywords	trk-a kinase domain, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35794.22
Authors	Subramanian, G. (deposition date: 2019-06-30, release date: 2019-09-04, Last modification date: 2024-03-13)
Primary citation	Subramanian, G.,Bowen, S.J.,Zhu, Y.,Roush, N.,Zachary, T.,Javens, C.,Williams, T.,Janssen, A.,Gonzales, A. Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA). Bioorg.Med.Chem.Lett., 29:126624-126624, 2019 Cited by PubMed: 31444087 DOI: 10.1016/j.bmcl.2019.126624 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation