6PL1

TRK-A IN COMPLEX WITH LIGAND 1B

6PL1 の概要

• エントリーDOI: 10.2210/pdb6pl1/pdb
• 分子名称: High affinity nerve growth factor receptor, N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
• 機能のキーワード: trk-a kinase domain high affinity nerve growth factor receptor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35921.22

構造登録者

Subramanian, G. (登録日: 2019-06-30, 公開日: 2019-10-09, 最終更新日: 2019-10-30)

• 主引用文献: Subramanian, G.,Zhu, Y.,Bowen, S.J.,Roush, N.,White, J.A.,Huczek, D.,Zachary, T.,Javens, C.,Williams, T.,Janssen, A.,Gonzales, A.; Lead identification and characterization of hTrkA type 2 inhibitors.; Bioorg.Med.Chem.Lett., 29:126680-126680, 2019; PubMed: 31610943; DOI: 10.1016/j.bmcl.2019.126680

実験手法

X-RAY DIFFRACTION (2.03 Å)