6PKC
Inhibition of Human Menin by VTP-50469
Summary for 6PKC
Entry DOI | 10.2210/pdb6pkc/pdb |
Descriptor | Menin,Menin, 5-fluoro-2-({4-[7-({trans-4-[(methylsulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N,N-di(propan-2-yl)benzamide (3 entities in total) |
Functional Keywords | human menin, transcription, inhibitor complex, vtp-50469 |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 110996.01 |
Authors | McKeever, B.M.,Chen, G.,Van Orton, R. (deposition date: 2019-06-29, release date: 2019-12-18, Last modification date: 2023-10-11) |
Primary citation | Krivtsov, A.V.,Evans, K.,Gadrey, J.Y.,Eschle, B.K.,Hatton, C.,Uckelmann, H.J.,Ross, K.N.,Perner, F.,Olsen, S.N.,Pritchard, T.,McDermott, L.,Jones, C.D.,Jing, D.,Braytee, A.,Chacon, D.,Earley, E.,McKeever, B.M.,Claremon, D.,Gifford, A.J.,Lee, H.J.,Teicher, B.A.,Pimanda, J.E.,Beck, D.,Perry, J.A.,Smith, M.A.,McGeehan, G.M.,Lock, R.B.,Armstrong, S.A. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell, 36:660-673.e11, 2019 Cited by PubMed: 31821784DOI: 10.1016/j.ccell.2019.11.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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