6PKA

Structure of ClpP from Staphylococcus aureus in complex with ureadepsipeptide

Summary for 6PKA

• Entry DOI: 10.2210/pdb6pka/pdb
• Related: 5VZ2 5W18
• Related PRD ID: PRD_002359
• Descriptor: ATP-dependent Clp protease proteolytic subunit, OO1-WFP-SER-PRO-YCP-ALA-MP8 ureadepsipeptide (3 entities in total)
• Functional Keywords: clpp adep, antibiotic, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Staphylococcus aureus (strain NCTC 8325); More
• Total number of polymer chains: 28
• Total formula weight: 327873.81

Authors

Griffith, E.C.,Lee, R.E. (deposition date: 2019-06-28, release date: 2019-11-06, Last modification date: 2023-11-15)

• Primary citation: Griffith, E.C.,Zhao, Y.,Singh, A.P.,Conlon, B.P.,Tangallapally, R.,Shadrick, W.R.,Liu, J.,Wallace, M.J.,Yang, L.,Elmore, J.M.,Li, Y.,Zheng, Z.,Miller, D.J.,Cheramie, M.N.,Lee, R.B.,LaFleur, M.D.,Lewis, K.,Lee, R.E.; Ureadepsipeptides as ClpP Activators.; Acs Infect Dis., 5:1915-1925, 2019; PubMed: 31588734; DOI: 10.1021/acsinfecdis.9b00245

Experimental method

X-RAY DIFFRACTION (2.25 Å)