6PGX

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

6PGX の概要

• エントリーDOI: 10.2210/pdb6pgx/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-[(2S)-2-hydroxy-3-{[(2R)-2-hydroxy-3-(4-sulfamoylphenoxy)propyl]tellanyl}propoxy]benzene-1-sulfonamide, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase inhibitors (cais), tellurium, metalloenzymes, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31303.02

構造登録者

Peat, T.S. (登録日: 2019-06-25, 公開日: 2019-08-21, 最終更新日: 2023-10-11)

• 主引用文献: Tanini, D.,Ricci, L.,Capperucci, A.,Di Cesare Mannelli, L.,Ghelardini, C.,Peat, T.S.,Carta, F.,Angeli, A.,Supuran, C.T.; Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.; Eur.J.Med.Chem., 181:111586-111586, 2019; PubMed: 31401537; DOI: 10.1016/j.ejmech.2019.111586

実験手法

X-RAY DIFFRACTION (1.36 Å)