6PGP

Crystal structure of human KRAS G12C covalently bound to a quinazolinone inhibitor

Summary for 6PGP

• Entry DOI: 10.2210/pdb6pgp/pdb
• Related: 6PGO
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, gtpase, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 44222.01

Authors

Mohr, C.,Whittington, D.A. (deposition date: 2019-06-24, release date: 2019-12-25, Last modification date: 2020-01-22)

• Primary citation: Lanman, B.A.,Allen, J.R.,Allen, J.G.,Amegadzie, A.K.,Ashton, K.S.,Booker, S.K.,Chen, J.J.,Chen, N.,Frohn, M.J.,Goodman, G.,Kopecky, D.J.,Liu, L.,Lopez, P.,Low, J.D.,Ma, V.,Minatti, A.E.,Nguyen, T.T.,Nishimura, N.,Pickrell, A.J.,Reed, A.B.,Shin, Y.,Siegmund, A.C.,Tamayo, N.A.,Tegley, C.M.,Walton, M.C.,Wang, H.L.,Wurz, R.P.,Xue, M.,Yang, K.C.,Achanta, P.,Bartberger, M.D.,Canon, J.,Hollis, L.S.,McCarter, J.D.,Mohr, C.,Rex, K.,Saiki, A.Y.,San Miguel, T.,Volak, L.P.,Wang, K.H.,Whittington, D.A.,Zech, S.G.,Lipford, J.R.,Cee, V.J.; Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors.; J.Med.Chem., 63:52-65, 2020; PubMed: 31820981; DOI: 10.1021/acs.jmedchem.9b01180

Experimental method

X-RAY DIFFRACTION (1.5 Å)