6PF6

Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid

6PF6 の概要

• エントリーDOI: 10.2210/pdb6pf6/pdb
• 分子名称: Thymidylate synthase,Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid, ... (4 entities in total)
• 機能のキーワード: inhibitor, ts, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 134883.81

構造登録者

Czyzyk, D.L.,Valhondo, M.,Jorgensen, W.L.,Anderson, K.S. (登録日: 2019-06-21, 公開日: 2019-10-16, 最終更新日: 2023-10-11)

• 主引用文献: Czyzyk, D.J.,Valhondo, M.,Deiana, L.,Tirado-Rives, J.,Jorgensen, W.L.,Anderson, K.S.; Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors.; Eur.J.Med.Chem., 183:111673-111673, 2019; PubMed: 31536894; DOI: 10.1016/j.ejmech.2019.111673

実験手法

X-RAY DIFFRACTION (2.502 Å)