6PER

Crystal Structure of Ligand-Free iSeroSnFR

Summary for 6PER

• Entry DOI: 10.2210/pdb6per/pdb
• Descriptor: iSeroSnFR, a soluble, genetically-encoded fluorescent sensor for serotonin, 1,2-ETHANEDIOL (3 entities in total)
• Functional Keywords: fluorescent sensor, serotonin binding protein, biosensor, fluorescent protein
• Biological source: Thermoanaerobacter sp. X513
• Total number of polymer chains: 1
• Total formula weight: 62570.82

Authors

Hartanto, S.,Tian, L.,Fisher, A.J. (deposition date: 2019-06-20, release date: 2020-06-24, Last modification date: 2023-11-15)

• Primary citation: Unger, E.K.,Keller, J.P.,Altermatt, M.,Liang, R.,Matsui, A.,Dong, C.,Hon, O.J.,Yao, Z.,Sun, J.,Banala, S.,Flanigan, M.E.,Jaffe, D.A.,Hartanto, S.,Carlen, J.,Mizuno, G.O.,Borden, P.M.,Shivange, A.V.,Cameron, L.P.,Sinning, S.,Underhill, S.M.,Olson, D.E.,Amara, S.G.,Temple Lang, D.,Rudnick, G.,Marvin, J.S.,Lavis, L.D.,Lester, H.A.,Alvarez, V.A.,Fisher, A.J.,Prescher, J.A.,Kash, T.L.,Yarov-Yarovoy, V.,Gradinaru, V.,Looger, L.L.,Tian, L.; Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.; Cell, 183:1986-2002.e26, 2020; PubMed: 33333022; DOI: 10.1016/j.cell.2020.11.040

Experimental method

X-RAY DIFFRACTION (2.1 Å)