6PE9

Crystal Structure of CD40 complexed to FAB516

6PE9 の概要

• エントリーDOI: 10.2210/pdb6pe9/pdb
• 分子名称: FAB Heavy chain, FAB Light chain, Tumor necrosis factor receptor superfamily member 5, ... (5 entities in total)
• 機能のキーワード: cd40, fab, complex, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 336555.13

構造登録者

Argiriadi, M.A. (登録日: 2019-06-20, 公開日: 2019-08-14, 最終更新日: 2024-10-16)

主引用文献

Argiriadi, M.A.,Benatuil, L.,Dubrovska, I.,Egan, D.A.,Gao, L.,Greischar, A.,Hardman, J.,Harlan, J.,Iyer, R.B.,Judge, R.A.,Lake, M.,Perron, D.C.,Sadhukhan, R.,Sielaff, B.,Sousa, S.,Wang, R.,McRae, B.L.
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
BMC Mol Cell Biol, 20:29-29, 2019

PubMed Abstract: CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of proinflammatory cytokines, induces T helper cell function, and promotes macrophage activation. The involvement of CD40 in chronic immune activation has resulted in CD40 being proposed as a therapeutic target for a range of chronic inflammatory diseases. CD40 antagonists are currently being explored for the treatment of autoimmune diseases and several anti-CD40 agonist mAbs have entered clinical development for oncological indications.

PubMed: 31382872
DOI: 10.1186/s12860-019-0213-4

実験手法

X-RAY DIFFRACTION (3.13 Å)