6P9E
Crystal structure of IL-36gamma complexed to A-552
Summary for 6P9E
Entry DOI | 10.2210/pdb6p9e/pdb |
Descriptor | Interleukin-36 gamma, (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid (3 entities in total) |
Functional Keywords | il-36, small molecule antagonist, cytokine |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17514.95 |
Authors | Argiriadi, M.A.,Todorovic, T.,Su, Z.,Putman, B.,Kakavas, S.J.,Salte, K.M.,McDonald, H.A.,Wetter, J.B.,Paulsboe, S.E.,Sun, Q.,Gerstein, C.E.,Medina, L.,Sielaff, B.,Sadhukhan, R.,Stockmann, H.,Richardson, P.L.,Qiu, W.,Henry, R.F.,Herold, J.M.,Shotwell, J.B.,McGaraughty, S.P.,Honore, P.,Gopalakrishnan, S.M.,Sun, C.C.,Scott, V.E. (deposition date: 2019-06-10, release date: 2019-06-26, Last modification date: 2023-10-11) |
Primary citation | Todorovic, V.,Su, Z.,Putman, C.B.,Kakavas, S.J.,Salte, K.M.,McDonald, H.A.,Wetter, J.B.,Paulsboe, S.E.,Sun, Q.,Gerstein, C.E.,Medina, L.,Sielaff, B.,Sadhukhan, R.,Stockmann, H.,Richardson, P.L.,Qiu, W.,Argiriadi, M.A.,Henry, R.F.,Herold, J.M.,Shotwell, J.B.,McGaraughty, S.P.,Honore, P.,Gopalakrishnan, S.M.,Sun, C.C.,Scott, V.E. Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep, 9:9089-9089, 2019 Cited by PubMed: 31235749DOI: 10.1038/s41598-019-45626-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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