6P8Q
EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.
Summary for 6P8Q
| Entry DOI | 10.2210/pdb6p8q/pdb |
| Descriptor | Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 10-benzyl-2-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, ... (7 entities in total) |
| Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 153070.51 |
| Authors | Yun, C.H.,Heppner, D.E.,Eck, M.J. (deposition date: 2019-06-07, release date: 2019-12-18, Last modification date: 2023-10-11) |
| Primary citation | De Clercq, D.J.H.,Heppner, D.E.,To, C.,Jang, J.,Park, E.,Yun, C.H.,Mushajiang, M.,Shin, B.H.,Gero, T.W.,Scott, D.A.,Janne, P.A.,Eck, M.J.,Gray, N.S. Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Acs Med.Chem.Lett., 10:1549-1553, 2019 Cited by PubMed: 31749909DOI: 10.1021/acsmedchemlett.9b00381 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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