6P8Q

EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor.

6P8Q の概要

• エントリーDOI: 10.2210/pdb6p8q/pdb
• 分子名称: Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 10-benzyl-2-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one, ... (7 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 153070.51

構造登録者

Yun, C.H.,Heppner, D.E.,Eck, M.J. (登録日: 2019-06-07, 公開日: 2019-12-18, 最終更新日: 2023-10-11)

• 主引用文献: De Clercq, D.J.H.,Heppner, D.E.,To, C.,Jang, J.,Park, E.,Yun, C.H.,Mushajiang, M.,Shin, B.H.,Gero, T.W.,Scott, D.A.,Janne, P.A.,Eck, M.J.,Gray, N.S.; Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.; Acs Med.Chem.Lett., 10:1549-1553, 2019; PubMed: 31749909; DOI: 10.1021/acsmedchemlett.9b00381

実験手法

X-RAY DIFFRACTION (1.9 Å)