6P6T

HCV NS3/4A protease domain of genotype 4a in complex with glecaprevir

Summary for 6P6T

• Entry DOI: 10.2210/pdb6p6t/pdb
• Descriptor: Non-structural protein 4A,Serine protease NS3, ZINC ION, Glecaprevir, ... (4 entities in total)
• Functional Keywords: hcv ns3/4a protease hcv protease domain glecaprevir, gle genotype 4a chimera, viral protein, hydrolase
• Biological source: Hepatitis C virus genotype 4a (isolate ED43) (HCV); More
• Total number of polymer chains: 1
• Total formula weight: 22130.39

Authors

Timm, J.,Schiffer, C.A. (deposition date: 2019-06-04, release date: 2020-06-10, Last modification date: 2025-01-29)

• Primary citation: Timm, J.,Kosovrasti, K.,Henes, M.,Leidner, F.,Hou, S.,Kurt-Yilmaz, N.,Schiffer, C.A.; Molecular mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir and characterization of genotype-specific structural differences; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)