6P6K
Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors
Summary for 6P6K
Entry DOI | 10.2210/pdb6p6k/pdb |
Related | 6P6G |
Descriptor | Histone-lysine N-methyltransferase SMYD3, ZINC ION, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | methyltranserase, oncology, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 50590.28 |
Authors | Elkins, P.A.,Wang, L. (deposition date: 2019-06-04, release date: 2020-01-15, Last modification date: 2024-03-13) |
Primary citation | Su, D.S.,Qu, J.,Schulz, M.,Blackledge, C.W.,Yu, H.,Zeng, J.,Burgess, J.,Reif, A.,Stern, M.,Nagarajan, R.,Pappalardi, M.B.,Wong, K.,Graves, A.P.,Bonnette, W.,Wang, L.,Elkins, P.,Knapp-Reed, B.,Carson, J.D.,McHugh, C.,Mohammad, H.,Kruger, R.,Luengo, J.,Heerding, D.A.,Creasy, C.L. Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11:133-140, 2020 Cited by PubMed: 32071679DOI: 10.1021/acsmedchemlett.9b00493 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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