6P5V

Structure of DCN1 bound to N-((4S,5S)-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-methylbenzamide

6P5V の概要

• エントリーDOI: 10.2210/pdb6p5v/pdb
• 分子名称: Lysozyme,DCN1-like protein 1 fusion, (4S)-2-METHYL-2,4-PENTANEDIOL, N-[(4S,5S)-1-[(1S)-cyclohex-3-en-1-yl]-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-methylbenzamide, ... (4 entities in total)
• 機能のキーワード: e3 ligase, ligase
• 由来する生物種: Enterobacteria phage T4; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44912.11

構造登録者

Guy, R.K.,Kim, H.S.,Hammill, J.T.,Scott, D.C.,Schulman, B.A. (登録日: 2019-05-31, 公開日: 2019-09-11, 最終更新日: 2023-10-11)

• 主引用文献: Kim, H.S.,Hammill, J.T.,Scott, D.C.,Chen, Y.,Min, J.,Rector, J.,Singh, B.,Schulman, B.A.,Guy, R.K.; Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation.; J.Med.Chem., 62:8429-8442, 2019; PubMed: 31465221; DOI: 10.1021/acs.jmedchem.9b00410

実験手法

X-RAY DIFFRACTION (1.398 Å)