6P4A

HyHEL10 Fab complexed with hen egg lysozyme carrying two mutations (HEL2x-rigid): R21Q and R73E

Summary for 6P4A

Entry DOI	10.2210/pdb6p4a/pdb
Descriptor	HyHEL10 Fab light chain, HyHEL10 Fab heavy chain, Lysozyme C, ... (4 entities in total)
Functional Keywords	hyhel10, hel2x-rigid, antibody-antigen, hyhel10-hel2x, hydrolase-immune system complex, hydrolase/immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	3
Total formula weight	62154.77
Authors	Langley, D.B.,Christ, D. (deposition date: 2019-05-27, release date: 2020-05-27, Last modification date: 2023-10-11)
Primary citation	Burnett, D.L.,Schofield, P.,Langley, D.B.,Jackson, J.,Bourne, K.,Wilson, E.,Porebski, B.T.,Buckle, A.M.,Brink, R.,Goodnow, C.C.,Christ, D. Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117:22341-22350, 2020 Cited by PubMed: 32855302 DOI: 10.1073/pnas.2005102117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation