6P4A

HyHEL10 Fab complexed with hen egg lysozyme carrying two mutations (HEL2x-rigid): R21Q and R73E

6P4A の概要

• エントリーDOI: 10.2210/pdb6p4a/pdb
• 分子名称: HyHEL10 Fab light chain, HyHEL10 Fab heavy chain, Lysozyme C, ... (4 entities in total)
• 機能のキーワード: hyhel10, hel2x-rigid, antibody-antigen, hyhel10-hel2x, hydrolase-immune system complex, hydrolase/immune system
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 62154.77

構造登録者

Langley, D.B.,Christ, D. (登録日: 2019-05-27, 公開日: 2020-05-27, 最終更新日: 2023-10-11)

• 主引用文献: Burnett, D.L.,Schofield, P.,Langley, D.B.,Jackson, J.,Bourne, K.,Wilson, E.,Porebski, B.T.,Buckle, A.M.,Brink, R.,Goodnow, C.C.,Christ, D.; Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens.; Proc.Natl.Acad.Sci.USA, 117:22341-22350, 2020; PubMed: 32855302; DOI: 10.1073/pnas.2005102117

実験手法

X-RAY DIFFRACTION (2.2 Å)