6P3P

Crystal structure of Mcl-1 in complex with compound 65

Summary for 6P3P

Entry DOI	10.2210/pdb6p3p/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, methyl N-(5-{[2-chloro-5-(trifluoromethyl)phenyl]sulfamoyl}-4-methylthiophene-2-carbonyl)-D-phenylalaninate (3 entities in total)
Functional Keywords	mcl-1, biaryl sulfonamide inhibitor, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18441.30
Authors	Toms, A.V.,Follows, B. (deposition date: 2019-05-24, release date: 2019-07-03, Last modification date: 2023-10-11)
Primary citation	Follows, B.,Fessler, S.,Baumeister, T.,Campbell, A.M.,Zablocki, M.M.,Li, H.,Gotur, D.,Wang, Z.,Zheng, X.,Molz, L.,Nguyen, C.,Herbertz, T.,Wang, L.,Bair, K. Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors. Bioorg.Med.Chem.Lett., 29:2375-2382, 2019 Cited by PubMed: 31235261 DOI: 10.1016/j.bmcl.2019.06.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation