6P3P

Crystal structure of Mcl-1 in complex with compound 65

6P3P の概要

• エントリーDOI: 10.2210/pdb6p3p/pdb
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, methyl N-(5-{[2-chloro-5-(trifluoromethyl)phenyl]sulfamoyl}-4-methylthiophene-2-carbonyl)-D-phenylalaninate (3 entities in total)
• 機能のキーワード: mcl-1, biaryl sulfonamide inhibitor, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18441.30

構造登録者

Toms, A.V.,Follows, B. (登録日: 2019-05-24, 公開日: 2019-07-03, 最終更新日: 2023-10-11)

• 主引用文献: Follows, B.,Fessler, S.,Baumeister, T.,Campbell, A.M.,Zablocki, M.M.,Li, H.,Gotur, D.,Wang, Z.,Zheng, X.,Molz, L.,Nguyen, C.,Herbertz, T.,Wang, L.,Bair, K.; Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors.; Bioorg.Med.Chem.Lett., 29:2375-2382, 2019; PubMed: 31235261; DOI: 10.1016/j.bmcl.2019.06.008

実験手法

X-RAY DIFFRACTION (1.61 Å)