6P3O

Tetrahydroprotoberberine N-methyltransferase in complex with (S)-cis-N-methylstylopine and S-adenosylhomocysteine

6P3O の概要

• エントリーDOI: 10.2210/pdb6p3o/pdb
• 分子名称: Tetrahydroprotoberberine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (5S,12bS)-5-methyl-6,7,12b,13-tetrahydro-2H,4H,10H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium, ... (4 entities in total)
• 機能のキーワード: methyltransferase, transferase
• 由来する生物種: Glaucium flavum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44524.71

構造登録者

Lang, D.E.,Morris, J.S.,Rowley, M.,Torres, M.A.,Maksimovich, V.A.,Facchini, P.J.,Ng, K.K.S. (登録日: 2019-05-24, 公開日: 2019-08-14, 最終更新日: 2023-10-11)

• 主引用文献: Lang, D.E.,Morris, J.S.,Rowley, M.,Torres, M.A.,Maksimovich, V.A.,Facchini, P.J.,Ng, K.K.S.; Structure-function studies of tetrahydroprotoberberineN-methyltransferase reveal the molecular basis of stereoselective substrate recognition.; J.Biol.Chem., 294:14482-14498, 2019; PubMed: 31395658; DOI: 10.1074/jbc.RA119.009214

実験手法

X-RAY DIFFRACTION (1.8 Å)