6P3D
The co-crystal structure of BRAF(V600E) with ponatinib
Summary for 6P3D
Entry DOI | 10.2210/pdb6p3d/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, SULFATE ION, ... (6 entities in total) |
Functional Keywords | kinase, inhibitor, cancer, melanoma, transferase-transferase inhibitor complex, oncoprotein, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35195.90 |
Authors | Agianian, B.,Gavathiotis, E. (deposition date: 2019-05-23, release date: 2020-09-23, Last modification date: 2024-03-13) |
Primary citation | Cotto-Rios, X.M.,Agianian, B.,Gitego, N.,Zacharioudakis, E.,Giricz, O.,Wu, Y.,Zou, Y.,Verma, A.,Poulikakos, P.I.,Gavathiotis, E. Inhibitors of BRAF dimers using an allosteric site. Nat Commun, 11:4370-4370, 2020 Cited by PubMed: 32873792DOI: 10.1038/s41467-020-18123-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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