6P26

Escherichia coli tRNA synthetase in complex with compound 1

6P26 の概要

• エントリーDOI: 10.2210/pdb6p26/pdb
• 分子名称: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, N-benzyl-2-(cyclohex-1-en-1-yl)ethan-1-amine (3 entities in total)
• 機能のキーワード: inhibitor, aminoacyl-trna synthetase, phers, antibacterial, ligase
• 由来する生物種: Escherichia coli str. K-12 substr. MG1655; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 250033.06

構造登録者

Kahne, D.,Baidin, V.,Owens, T.W. (登録日: 2019-05-21, 公開日: 2020-11-18, 最終更新日: 2023-10-11)

• 主引用文献: Baidin, V.,Owens, T.W.,Lazarus, M.B.,Kahne, D.; Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.; J.Am.Chem.Soc., 143:623-627, 2021; PubMed: 33411531; DOI: 10.1021/jacs.0c11113

実験手法

X-RAY DIFFRACTION (3.16 Å)