6P12
Structure of spastin AAA domain (wild-type) in complex with diaminotriazole-based inhibitor
Summary for 6P12
| Entry DOI | 10.2210/pdb6p12/pdb |
| Descriptor | Drosophila melanogaster Spastin AAA domain, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | inhibitor, complex, aaa protein, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
| Biological source | Drosophila melanogaster (Fruit fly) |
| Total number of polymer chains | 1 |
| Total formula weight | 34790.45 |
| Authors | Pisa, R.,Cupido, T.,Kapoor, T.M. (deposition date: 2019-05-17, release date: 2019-07-24, Last modification date: 2023-10-11) |
| Primary citation | Pisa, R.,Cupido, T.,Steinman, J.B.,Jones, N.H.,Kapoor, T.M. Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins. Cell Chem Biol, 26:1263-, 2019 Cited by PubMed: 31257183DOI: 10.1016/j.chembiol.2019.06.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9413185678 Å) |
Structure validation
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