6P12

Structure of spastin AAA domain (wild-type) in complex with diaminotriazole-based inhibitor

6P12 の概要

• エントリーDOI: 10.2210/pdb6p12/pdb
• 分子名称: Drosophila melanogaster Spastin AAA domain, 3-{[5-amino-1-(2-fluoro-6-methoxybenzene-1-carbonyl)-1H-1,2,4-triazol-3-yl]amino}-N-methylbenzamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, aaa protein, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34790.45

構造登録者

Pisa, R.,Cupido, T.,Kapoor, T.M. (登録日: 2019-05-17, 公開日: 2019-07-24, 最終更新日: 2023-10-11)

• 主引用文献: Pisa, R.,Cupido, T.,Steinman, J.B.,Jones, N.H.,Kapoor, T.M.; Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.; Cell Chem Biol, 26:1263-, 2019; PubMed: 31257183; DOI: 10.1016/j.chembiol.2019.06.001

実験手法

X-RAY DIFFRACTION (1.9413185678 Å)