6P0I

Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds.

6P0I の概要

• エントリーDOI: 10.2210/pdb6p0i/pdb
• 分子名称: Ras-related protein Ral-A, GUANOSINE-5'-DIPHOSPHATE, 1,2-ETHANEDIOL, ... (10 entities in total)
• 機能のキーワード: ral gtpase, rala, covalent inhibitor, sulfonyl fluoride, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22474.05

構造登録者

Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Liu, D.,Ghozayel, M.K.,Xu, D.,Meroueh, S.O. (登録日: 2019-05-17, 公開日: 2020-03-04, 最終更新日: 2023-10-11)

• 主引用文献: Bum-Erdene, K.,Liu, D.,Gonzalez-Gutierrez, G.,Ghozayel, M.K.,Xu, D.,Meroueh, S.O.; Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases.; Proc.Natl.Acad.Sci.USA, 117:7131-7139, 2020; PubMed: 32179690; DOI: 10.1073/pnas.1913654117

実験手法

X-RAY DIFFRACTION (1.18 Å)