6OYW

ASK1 kinase domain in complex with Compound 11

Summary for 6OYW

Entry DOI	10.2210/pdb6oyw/pdb
Descriptor	Mitogen-activated protein kinase kinase kinase 5, (19S)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9H)-one, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	ask1 map3k5, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	133680.55
Authors	Marcotte, D.J. (deposition date: 2019-05-15, release date: 2019-11-27, Last modification date: 2023-10-11)
Primary citation	Himmelbauer, M.K.,Xin, Z.,Jones, J.H.,Enyedy, I.,King, K.,Marcotte, D.J.,Murugan, P.,Santoro, J.C.,Hesson, T.,Spilker, K.,Johnson, J.L.,Luzzio, M.J.,Gilfillan, R.,de Turiso, F.G. Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors. J.Med.Chem., 62:10740-10756, 2019 Cited by PubMed: 31710475 DOI: 10.1021/acs.jmedchem.9b01206 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.603 Å)

Structure validation