6OYT

ASK1 kinase domain in complex with GS-4997

6OYT の概要

• エントリーDOI: 10.2210/pdb6oyt/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase 5, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: ask1 map3k5, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129121.81

構造登録者

Marcotte, D.J. (登録日: 2019-05-15, 公開日: 2019-11-27, 最終更新日: 2023-10-11)

• 主引用文献: Himmelbauer, M.K.,Xin, Z.,Jones, J.H.,Enyedy, I.,King, K.,Marcotte, D.J.,Murugan, P.,Santoro, J.C.,Hesson, T.,Spilker, K.,Johnson, J.L.,Luzzio, M.J.,Gilfillan, R.,de Turiso, F.G.; Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.; J.Med.Chem., 62:10740-10756, 2019; PubMed: 31710475; DOI: 10.1021/acs.jmedchem.9b01206

実験手法

X-RAY DIFFRACTION (2.824 Å)