6OYH

Crystal structure of MraY bound to carbacaprazamycin

Summary for 6OYH

• Entry DOI: 10.2210/pdb6oyh/pdb
• Descriptor: MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase, (5S)-5'-O-(5-amino-5-deoxy-beta-D-ribofuranosyl)-5'-C-[(2S,5S,6S)-5-carboxy-6-heptadecyl-1,4-dimethyl-3-oxo-1,4-diazepan-2-yl]uridine, ... (4 entities in total)
• Functional Keywords: peptidoglycan biosynthesis, antibiotic target, integral membrane enzyme, translocase, membrane protein, membrane protein-transferase complex, membrane protein/transferase
• Biological source: Lama glama (llama); More
• Total number of polymer chains: 8
• Total formula weight: 227241.24

Authors

Mashalidis, E.H.,Lee, S.Y. (deposition date: 2019-05-14, release date: 2019-07-10, Last modification date: 2023-10-11)

• Primary citation: Mashalidis, E.H.,Kaeser, B.,Terasawa, Y.,Katsuyama, A.,Kwon, D.Y.,Lee, K.,Hong, J.,Ichikawa, S.,Lee, S.Y.; Chemical logic of MraY inhibition by antibacterial nucleoside natural products.; Nat Commun, 10:2917-2917, 2019; PubMed: 31266949; DOI: 10.1038/s41467-019-10957-9

Experimental method

X-RAY DIFFRACTION (2.95 Å)