6OXD

Structure of Mycobacterium tuberculosis methylmalonyl-CoA mutase with adenosyl cobalamin

6OXD の概要

• エントリーDOI: 10.2210/pdb6oxd/pdb
• 関連するPDBエントリー: 6OXC
• 分子名称: Methylmalonyl-CoA mutase large subunit, Methylmalonyl-CoA mutase small subunit, COBALAMIN, ... (7 entities in total)
• 機能のキーワード: methylmalonyl coa mutase, methylmalonyl coa mutase deficiency, metabolic disease, cobalamin, cobalt, disease mutation, isomerase, metal-binding, itaconyl coa, radical, mycobacterium tuberculosis, immunometabolite, b12, methylmalonic aciduria
• 由来する生物種: Mycobacterium tuberculosis; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 148063.54

構造登録者

Purchal, M.,Ruetz, M.,Banerjee, R.,Koutmos, M. (登録日: 2019-05-13, 公開日: 2019-11-13, 最終更新日: 2023-10-11)

• 主引用文献: Ruetz, M.,Campanello, G.C.,Purchal, M.,Shen, H.,McDevitt, L.,Gouda, H.,Wakabayashi, S.,Zhu, J.,Rubin, E.J.,Warncke, K.,Mootha, V.K.,Koutmos, M.,Banerjee, R.; Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair.; Science, 366:589-593, 2019; PubMed: 31672889; DOI: 10.1126/science.aay0934

実験手法

X-RAY DIFFRACTION (2 Å)