6OXC

Structure of Mycobacterium tuberculosis methylmalonyl-CoA mutase with adenosyl cobalamin

Summary for 6OXC

Entry DOI	10.2210/pdb6oxc/pdb
Related	6OXD
Descriptor	Methylmalonyl-CoA mutase large subunit, Methylmalonyl-CoA mutase small subunit mutA, COBALAMIN, ... (5 entities in total)
Functional Keywords	methylmalonyl coa mutase, methylmalonyl coa mutase deficiency, metabolic disease, cobalamin, cobalt, disease mutation, isomerase, metal-binding, itaconyl coa, radical, mycobacterium tuberculosis, immunometabolite, b12, methylmalonic aciduria
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	2
Total formula weight	147142.80
Authors	Purchal, M.,Ruetz, M.,Banerjee, R.,Koutmos, M. (deposition date: 2019-05-13, release date: 2019-11-13, Last modification date: 2023-10-11)
Primary citation	Ruetz, M.,Campanello, G.C.,Purchal, M.,Shen, H.,McDevitt, L.,Gouda, H.,Wakabayashi, S.,Zhu, J.,Rubin, E.J.,Warncke, K.,Mootha, V.K.,Koutmos, M.,Banerjee, R. Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. Science, 366:589-593, 2019 Cited by PubMed: 31672889 DOI: 10.1126/science.aay0934 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation