6OW0

Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+ and PEG

Summary for 6OW0

Entry DOI	10.2210/pdb6ow0/pdb
Descriptor	MtmW, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	natural product, biosynthesis, aureolic acid, reductase, oxidoreductase
Biological source	Streptomyces argillaceus
Total number of polymer chains	2
Total formula weight	74451.82
Authors	Hou, C.,Yu, X.,Rohr, J.,Tsodikov, O.V. (deposition date: 2019-05-08, release date: 2019-11-27, Last modification date: 2023-10-11)
Primary citation	Wheeler, R.,Yu, X.,Hou, C.,Mitra, P.,Chen, J.M.,Herkules, F.,Ivanov, D.N.,Tsodikov, O.V.,Rohr, J. Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59:826-832, 2020 Cited by PubMed: 31702856 DOI: 10.1002/anie.201910241 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation