6OVX
Crystal structure of mithramycin 3-side chain keto-reductase MtmW in complex with NAD+, P422 form
Summary for 6OVX
| Entry DOI | 10.2210/pdb6ovx/pdb |
| Descriptor | Putative side chain reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | natural product, biosynthesis, aureolic acid, reductase, oxidoreductase |
| Biological source | Streptomyces argillaceus |
| Total number of polymer chains | 2 |
| Total formula weight | 74345.70 |
| Authors | Hou, C.,Yu, X.,Rohr, J.,Tsodikov, O.V. (deposition date: 2019-05-08, release date: 2019-11-27, Last modification date: 2023-10-11) |
| Primary citation | Wheeler, R.,Yu, X.,Hou, C.,Mitra, P.,Chen, J.M.,Herkules, F.,Ivanov, D.N.,Tsodikov, O.V.,Rohr, J. Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew.Chem.Int.Ed.Engl., 59:826-832, 2020 Cited by PubMed: 31702856DOI: 10.1002/anie.201910241 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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