6OTZ
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (+)FTC-TP
Summary for 6OTZ
Entry DOI | 10.2210/pdb6otz/pdb |
Related | 6OR7 |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, DNA Primer 20-mer, ... (9 entities in total) |
Functional Keywords | reverse transcriptase, ternary complex, (-)ftc-tp, chain terminator, emtricitabine, stereochemistry, transferase, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) More |
Total number of polymer chains | 4 |
Total formula weight | 132842.74 |
Authors | Bertoletti, N.,Anderson, K.S. (deposition date: 2019-05-03, release date: 2019-07-24, Last modification date: 2023-10-11) |
Primary citation | Bertoletti, N.,Chan, A.H.,Schinazi, R.F.,Yin, Y.W.,Anderson, K.S. Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine. Protein Sci., 28:1664-1675, 2019 Cited by PubMed: 31301259DOI: 10.1002/pro.3681 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.857 Å) |
Structure validation
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