6OSH

Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2

Summary for 6OSH

• Entry DOI: 10.2210/pdb6osh/pdb
• Descriptor: Antibody Light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2, Antibody heavy chain variable region, ... (4 entities in total)
• Functional Keywords: single chain fv, scfv, antibody, ror2, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system
• Biological source: Oryctolagus cuniculus; More
• Total number of polymer chains: 3
• Total formula weight: 35018.85

Authors

Park, H.,Rader, C. (deposition date: 2019-05-01, release date: 2020-04-01, Last modification date: 2023-10-11)

• Primary citation: Goydel, R.S.,Weber, J.,Peng, H.,Qi, J.,Soden, J.,Freeth, J.,Park, H.,Rader, C.; Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.; J.Biol.Chem., 295:5995-6006, 2020; PubMed: 32193207; DOI: 10.1074/jbc.RA120.012791

Experimental method

X-RAY DIFFRACTION (1.117 Å)