6OSH
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Summary for 6OSH
Entry DOI | 10.2210/pdb6osh/pdb |
Descriptor | Antibody Light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2, Antibody heavy chain variable region, ... (4 entities in total) |
Functional Keywords | single chain fv, scfv, antibody, ror2, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system |
Biological source | Oryctolagus cuniculus More |
Total number of polymer chains | 3 |
Total formula weight | 35018.85 |
Authors | |
Primary citation | Goydel, R.S.,Weber, J.,Peng, H.,Qi, J.,Soden, J.,Freeth, J.,Park, H.,Rader, C. Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications. J.Biol.Chem., 295:5995-6006, 2020 Cited by PubMed: 32193207DOI: 10.1074/jbc.RA120.012791 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.117 Å) |
Structure validation
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