6OSH

Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2

6OSH の概要

• エントリーDOI: 10.2210/pdb6osh/pdb
• 分子名称: Antibody Light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2, Antibody heavy chain variable region, ... (4 entities in total)
• 機能のキーワード: single chain fv, scfv, antibody, ror2, kringle domain, receptor tyrosine kinase-like orphan receptor, phage display, immune system
• 由来する生物種: Oryctolagus cuniculus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35018.85

構造登録者

Park, H.,Rader, C. (登録日: 2019-05-01, 公開日: 2020-04-01, 最終更新日: 2023-10-11)

• 主引用文献: Goydel, R.S.,Weber, J.,Peng, H.,Qi, J.,Soden, J.,Freeth, J.,Park, H.,Rader, C.; Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.; J.Biol.Chem., 295:5995-6006, 2020; PubMed: 32193207; DOI: 10.1074/jbc.RA120.012791

実験手法

X-RAY DIFFRACTION (1.117 Å)