6OS2

Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to TRV026

Summary for 6OS2

• Entry DOI: 10.2210/pdb6os2/pdb
• Descriptor: Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein, Nanobody Nb.AT110i1_le, TRV026 peptide, ... (7 entities in total)
• Functional Keywords: gpcr, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 65963.19

Authors

Wingler, L.M.,Staus, D.P.,Skiba, M.A.,McMahon, C.,Kleinhenz, A.L.W.,Lefkowitz, R.J.,Kruse, A.C. (deposition date: 2019-05-01, release date: 2020-02-19, Last modification date: 2023-10-11)

• Primary citation: Wingler, L.M.,Skiba, M.A.,McMahon, C.,Staus, D.P.,Kleinhenz, A.L.W.,Suomivuori, C.M.,Latorraca, N.R.,Dror, R.O.,Lefkowitz, R.J.,Kruse, A.C.; Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.; Science, 367:888-892, 2020; PubMed: 32079768; DOI: 10.1126/science.aay9813

Experimental method

X-RAY DIFFRACTION (2.7 Å)