6OS0

Structure of synthetic nanobody-stabilized angiotensin II type 1 receptor bound to angiotensin II

Summary for 6OS0

Entry DOI	10.2210/pdb6os0/pdb
Descriptor	Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein, Nanobody Nb.AT110i1, Angiotensinogen, ... (6 entities in total)
Functional Keywords	gpcr, nanobody, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	63567.21
Authors	Wingler, L.M.,Staus, D.P.,Skiba, M.A.,McMahon, C.,Kleinhenz, A.L.W.,Lefkowitz, R.J.,Kruse, A.C. (deposition date: 2019-05-01, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citation	Wingler, L.M.,Skiba, M.A.,McMahon, C.,Staus, D.P.,Kleinhenz, A.L.W.,Suomivuori, C.M.,Latorraca, N.R.,Dror, R.O.,Lefkowitz, R.J.,Kruse, A.C. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science, 367:888-892, 2020 Cited by PubMed: 32079768 DOI: 10.1126/science.aay9813 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation