6OR1

Human LRH-1 bound to the agonist 2N and a fragment of the Tif2 coregulator

Summary for 6OR1

Entry DOI	10.2210/pdb6or1/pdb
Descriptor	Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]acetamide, ... (4 entities in total)
Functional Keywords	nuclear receptor, coactivator, agonist, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	30568.35
Authors	Mays, S.G.,Ortlund, E.A. (deposition date: 2019-04-29, release date: 2019-08-28, Last modification date: 2023-10-11)
Primary citation	Mays, S.G.,Flynn, A.R.,Cornelison, J.L.,Okafor, C.D.,Wang, H.,Wang, G.,Huang, X.,Donaldson, H.N.,Millings, E.J.,Polavarapu, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A. Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J.Med.Chem., 62:11022-11034, 2019 Cited by PubMed: 31419141 DOI: 10.1021/acs.jmedchem.9b00753 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.174 Å)

Structure validation